Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.

Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.

Von Willebrand factor (VWF) is a pro-hemostatic multimeric plasma protein that promotes platelet aggregation and stabilizes coagulation factor VIII (FVIII) in plasma. The metalloproteinase ADAMTS13 regulates the platelet aggregation function of VWF via proteolysis. Severe deficiency of ADAMTS13 is a...

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Bibliographic Details
Main Authors: Martine J Hollestelle, Ka Wai Lai, Marcel van Deuren, Peter J Lenting, Philip G de Groot, Tom Sprong, Niels Bovenschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3164717?pdf=render

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http://europepmc.org/articles/PMC3164717?pdf=render

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