Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

Background: Due to the high reactivity towards various C-nucleophiles, trifluoromethylketimines are known to be useful reagents for the synthesis of α-trifluoromethylated amine derivatives. However, decarboxylative reactions with malonic acid and its mono(thio)esters have been poorly investigated so...

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Bibliographic Details
Main Authors: Sergii V. Melnykov, Andrii S. Pataman, Yurii V. Dmytriv, Svitlana V. Shishkina, Mykhailo V. Vovk, Volodymyr A. Sukach
Format: Article
Language:English
Published: Beilstein-Institut 2017-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
ketimines
malonic acid
Michael- and Mannich-type decarboxylative addition
pyrimidin-2(1H)-ones
regioselectivity
trifluoromethyl group
Online Access:https://doi.org/10.3762/bjoc.13.259

Internet

https://doi.org/10.3762/bjoc.13.259

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