Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.

Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.

We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor. We initially looked for unbalanced genomic rearrangements in the Sox2 locus in 42 GBM samples and found that Sox2...

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Bibliographic Details
Main Authors: Marta M Alonso, Ricardo Diez-Valle, Lorea Manterola, Angel Rubio, Dan Liu, Nahir Cortes-Santiago, Leire Urquiza, Patricia Jauregi, Adolfo Lopez de Munain, Nicolás Sampron, Ander Aramburu, Sonia Tejada-Solís, Carmen Vicente, María D Odero, Eva Bandrés, Jesús García-Foncillas, Miguel A Idoate, Frederick F Lang, Juan Fueyo, Candelaria Gomez-Manzano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3206066?pdf=render

Internet

http://europepmc.org/articles/PMC3206066?pdf=render

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