Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumulation of reactive oxygen species. The effect of lap...

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Bibliographic Details
Main Authors: Noëmi Johanna Roos, Diell Aliu, Jamal Bouitbir, Stephan Krähenbühl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
lapatinib
HepG2 cells
mitochondria
reactive oxygen species
Nrf2
Keap1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00944/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00944/full

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