Selective transmission of R5 HIV-1 variants: where is the gatekeeper?

<p>Abstract</p> <p>To enter target cells HIV-1 uses CD4 and a coreceptor. <it>In vivo</it> the coreceptor function is provided either by CCR5 (for R5) or CXCR4 (for X4 HIV-1). Although both R5 and X4 HIV-1 variants are present in body fluids (semen, blood, cervicovagina...

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Bibliographic Details
Main Authors: Grivel Jean-Charles, Shattock Robin J, Margolis Leonid B
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/9/S1/S6