Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the mechanism by which Stat3 regulates both cell aut...

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Bibliographic Details
Main Authors: Mara De Martino, Mercedes Tkach, Sofía Bruni, Darío Rocha, María F. Mercogliano, Mauro E. Cenciarini, María F. Chervo, Cecilia J. Proietti, Florent Dingli, Damarys Loew, Elmer A. Fernández, Patricia V. Elizalde, Eliane Piaggio, Roxana Schillaci
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
stat3
immunotherapy
senescence
oncogene addiction
immune checkpoint blockade
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1715767

Internet

http://dx.doi.org/10.1080/2162402X.2020.1715767

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