Targeting Bcl-2 Proteins in Acute Myeloid Leukemia

Targeting Bcl-2 Proteins in Acute Myeloid Leukemia

B cell lymphoma 2 (BCL-2) family proteins play an important role in intrinsic apoptosis. Overexpression of BCL-2 proteins in acute myeloid leukemia can circumvent resistance to apoptosis and chemotherapy. Considering this effect, the exploration of anti-apoptotic BCL-2 inhibitors is considered to ha...

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Bibliographic Details
Main Authors: Yunxiong Wei, Yaqing Cao, Rui Sun, Lin Cheng, Xia Xiong, Xin Jin, Xiaoyuan He, Wenyi Lu, Mingfeng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
B cell lymphoma 2
AML—acute myeloid leukemia
venetoclax (ABT-199)
intrinsic apoptosis
Bcl-2 protein
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.584974/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.584974/full

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