Glucose-impaired Corneal Re-epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate

Glucose-impaired Corneal Re-epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate

Glucose induces corneal epithelial dysfunctions characterized by delayed wound repair. Nuclear erythroid 2-related factor 2 (Nrf2) mediates cell protection mechanisms even through the Heme oxygenase-1 (HO-1) up-regulation. Here, we synthesized new HO-1 inducers by modifying dimethyl fumarate (DMF) a...

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Bibliographic Details
Main Authors: Giovanni Giurdanella, Anna Longo, Loredana Salerno, Giuseppe Romeo, Sebastiano Intagliata, Gabriella Lupo, Alfio Distefano, Chiara Bianca Maria Platania, Claudio Bucolo, Giovanni Li Volti, Carmelina Daniela Anfuso, Valeria Pittalà
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Antioxidants
Subjects:
SIRC
corneal epithelial cells
high glucose
Nrf2
wound healing
dimethyl fumarate
Online Access:https://www.mdpi.com/2076-3921/10/6/831

Internet

https://www.mdpi.com/2076-3921/10/6/831

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