Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication

Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication

Influenza A virus is a major global pathogen of humans, and there is an unmet need for effective antivirals. Current antivirals against influenza A virus directly target the virus and are vulnerable to mutational resistance. Harnessing an effective host antiviral response is an attractive alternativ...

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Bibliographic Details
Main Authors: Leah V. Goulding, Jiayun Yang, Zhimin Jiang, Hongyu Zhang, Daniel Lea, Richard D. Emes, Tania Dottorini, Juan Pu, Jinhua Liu, Kin-Chow Chang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
thapsigargin
endoplasmic reticulum stress
unfolded protein response
antiviral
influenza A virus
innate immunity
Online Access:https://www.mdpi.com/1999-4915/12/10/1093

Internet

https://www.mdpi.com/1999-4915/12/10/1093

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