Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5

Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5

We report the pattern of transgene expression across brain regions after intrathecal delivery of adeno-associated virus serotype 5 (AAV5). Labeling in hindbrain appeared to be primarily neuronal, and was detected in sensory nuclei of medulla, pontine nuclei, and all layers of cerebellar cortex. Expr...

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Bibliographic Details
Main Authors: Daniel J. Schuster, Lalitha R. Belur, Maureen S. Riedl, Stephen A. Schnell, Kelly M. Podetz-Pedersen, Kelley F. Kitto, R. Scott McIvor, Lucy eVulchanova, Carolyn A. Fairbanks
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Neuroanatomy
Subjects:
Mannitol
CNS
Adeno-Associated
AAV5
Intrathecal
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00066/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00066/full

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