Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels.

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels.

Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis. The prevailing model postulates that hexokinase II release from its mitochondrial interactor, the voltage-depend...

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Bibliographic Details
Main Authors: Federica Chiara, Diego Castellaro, Oriano Marin, Valeria Petronilli, William S Brusilow, Magdalena Juhaszova, Steven J Sollott, Michael Forte, Paolo Bernardi, Andrea Rasola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2267038?pdf=render

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http://europepmc.org/articles/PMC2267038?pdf=render

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