Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

Summary: Adaptive drug-resistance mechanisms allow human tumors to evade treatment through selection and expansion of treatment-resistant clones. Here, studying clonal evolution of tumor cells derived from human pancreatic tumors, we demonstrate that in vitro cultures and in vivo tumors are maintain...

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Bibliographic Details
Main Authors: Sahil Seth, Chieh-Yuan Li, I-Lin Ho, Denise Corti, Sara Loponte, Luigi Sapio, Edoardo Del Poggetto, Er-Yen Yen, Frederick Scott Robinson, Michael Peoples, Tatiana Karpinets, Angela Kay Deem, Tapsi Kumar, Xingzhi Song, Shan Jiang, Ya’an Kang, Jason Fleming, Michael Kim, Jianhua Zhang, Anirban Maitra, Timothy Paul Heffernan, Virginia Giuliani, Giannicola Genovese, Andrew Futreal, Giulio Francesco Draetta, Alessandro Carugo, Andrea Viale
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471930066X

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http://www.sciencedirect.com/science/article/pii/S221112471930066X

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