The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment

The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment

Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of neutrophil biology. PIP3 is subject to dephosphorylation by several 5’ phos...

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Bibliographic Details
Main Authors: Melina Michael, Barry McCormick, Karen E. Anderson, Utsa Karmakar, Matthieu Vermeren, Stéphane Schurmans, Augustin Amour, Sonja Vermeren
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
neutrophil
chemotaxis
recruitment
PI3K
SHIP2
SHIP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.671756/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.671756/full

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