Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer

Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer

Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analy...

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Bibliographic Details
Main Authors: Artemy D. Beniaminov, Grigory A. Puzanov, George S. Krasnov, Dmitry N. Kaluzhny, Tatiana P. Kazubskaya, Eleonora A. Braga, Anna V. Kudryavtseva, Nataliya V. Melnikova, Alexey A. Dmitriev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Genetics
Subjects:
ALDH1L1
breast cancer
expression downregulation
DNA methylation
deep sequencing
qPCR
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00169/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2018.00169/full

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