FK506 binding protein 12.6 knockout exacerbates detrusor overactivity in mice possibly by down-regulating ryanodine receptor 2

FK506 binding protein 12.6 knockout exacerbates detrusor overactivity in mice possibly by down-regulating ryanodine receptor 2

Objective To investigate the effect of FK506 binding protein 12.6 (FKBP12.6) knockout on detrusor overactivity (DO) in mice and explore the possible mechanism. Methods Mouse models of DO were established by partial bladder outlet obstruction (PBOO) in 30 wild-type mice (WT) and 30 homozygote FKBP12....

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Bibliographic Details
Main Authors: ZHOU Hao, WANG Jun, JI Guangju, ZHENG Ji, ZHOU Zhansong
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2019-11-01
Series:Di-san junyi daxue xuebao
Subjects:
fk506 binding protein 12.6
urinary bladder overactive
ryanodine receptor 2
mice
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201907042.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/201907042.htm

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