Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer

Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer

Abstract Background Pediatric high-grade gliomas (pHGGs) are incurable malignant brain cancers. Clear somatic genetic drivers are difficult to identify in the majority of cases. We hypothesized that this may be due to the existence of germline variants that influence tumor etiology and/or progressio...

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Bibliographic Details
Main Authors: Anna Bobyn, Mehdi Zarrei, Yuankun Zhu, Mary Hoffman, Darren Brenner, Adam C. Resnick, Stephen W. Scherer, Marco Gallo
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Medical Genetics
Subjects:
Whole-genome sequencing
Single-cell RNA-seq
Pediatric high-grade glioma
Germline variants
Online Access:http://link.springer.com/article/10.1186/s12881-020-01033-x

Internet

http://link.springer.com/article/10.1186/s12881-020-01033-x

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