Protective effects of plant seed extracts against amyloid β-induced neurotoxicity in cultured hippocampal neurons

Protective effects of plant seed extracts against amyloid β-induced neurotoxicity in cultured hippocampal neurons

Aim: Alzheimer′s disease (AD) is characterized by large deposits of amyloid β (Aβ) peptide. Aβ is known to increase reactive oxygen species (ROS) production in neurons, leading to cell death. In this study, we screened 15 plant seeds′ aqueous extracts (PSAE) for inhibitory effects on Aβ (25-35)-indu...

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Bibliographic Details
Main Authors: Yoshinori Okada, Mizue Okada
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
2-diphenyl-1-picryl-hydrazyl
amyloid β
cell viability
hippocampal neurons
phenolic compounds
plant seeds
radical scavenging
tumor necrosi factor-alpha
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=2;spage=141;epage=147;aulast=Okada

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http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=2;spage=141;epage=147;aulast=Okada

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