CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL progenitor cells (OPCs) in tr...

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Bibliographic Details
Main Authors: Penelope Dimas, Laura Montani, Jorge A Pereira, Daniel Moreno, Martin Trötzmüller, Joanne Gerber, Clay F Semenkovich, Harald C Köfeler, Ueli Suter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
myelination
oligodendrocytes
remyelination
fatty acid synthesis
high fat diet
myelin lipids
Online Access:https://elifesciences.org/articles/44702

Internet

https://elifesciences.org/articles/44702

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