Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression

Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression

Summary: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation. Lymph nodes of Cd53−/− mice were smaller than those of wild-type mice due to a marked reducti...

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Bibliographic Details
Main Authors: Maria C. Demaria, Louisa Yeung, Rens Peeters, Janet L. Wee, Masa Mihaljcic, Eleanor L. Jones, Zeyad Nasa, Frank Alderuccio, Pamela Hall, Brodie C. Smith, Katrina J. Binger, Gunther Hammerling, Hang Fai Kwok, Andrew Newman, Ann Ager, Annemiek van Spriel, Michael J. Hickey, Mark D. Wright
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Molecular Mechanism of Behavior
Immunology
Immune Response
Specialized Functions of Cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302893

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220302893

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