Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss

Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In neurons, these organelles are classified as synaptic and non-synaptic mitochondria depending on their localization. Interestingly, synaptic mitochondria from the cerebral cortex accumulate more damage and are...

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Bibliographic Details
Main Authors: Margrethe A. Olesen, Angie K. Torres, Claudia Jara, Michael P. Murphy, Cheril Tapia-Rojas
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720304122