Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection.

Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection.

The Loeys-Dietz syndrome (LDS) is an inherited connective tissue disorder caused by mutations in the transforming growth factor β (TGF-β) receptors TGFBR1 or TGFBR2. Most patients with LDS develop severe aortic aneurysms resulting in early need of surgical intervention. In order to gain further insi...

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Bibliographic Details
Main Authors: Jasmin Wellbrock, Sara Sheikhzadeh, Leticia Oliveira-Ferrer, Hauke Stamm, Mathias Hillebrand, Britta Keyser, Marianne Klokow, Gabi Vohwinkel, Veronika Bonk, Benjamin Otto, Thomas Streichert, Stefan Balabanov, Christian Hagel, Meike Rybczynski, Frank Bentzien, Carsten Bokemeyer, Yskert von Kodolitsch, Walter Fiedler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130545?pdf=render

Internet

http://europepmc.org/articles/PMC4130545?pdf=render

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