Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrat...

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Bibliographic Details
Main Authors: Marc A Kerenyi, Zhen Shao, Yu-Jung Hsu, Guoji Guo, Sidinh Luc, Kassandra O'Brien, Yuko Fujiwara, Cong Peng, Minh Nguyen, Stuart H Orkin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-06-01
Series:eLife
Subjects:
histone demethylase
Lsd1
KDM1
HSC
granulocyte
enhancer
Online Access:https://elifesciences.org/articles/00633

Internet

https://elifesciences.org/articles/00633

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