Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.

Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.

BACKGROUND:Although implicated in the pathogenesis of several chronic inflammatory disorders and hematologic malignancies, telomerase mutations have not been thoroughly characterized in human cancers. The present study was performed to examine the frequency and potential clinical relevance of telome...

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Bibliographic Details
Main Authors: Yuwei Zhang, Rodrigo Calado, Mahadev Rao, Julie A Hong, Alan K Meeker, Bogdan Dumitriu, Scott Atay, Peter J McCormick, Susan H Garfield, Danny Wangsa, Hesed M Padilla-Nash, Sandra Burkett, Mary Zhang, Tricia F Kunst, Nathan R Peterson, Sichuan Xi, Suzanne Inchauste, Nasser K Altorki, Alan G Casson, David G Beer, Curtis C Harris, Thomas Ried, Neal S Young, David S Schrump
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4077737?pdf=render

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http://europepmc.org/articles/PMC4077737?pdf=render

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