Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

Chemokines promote directional cell migration through binding to G-protein-coupled receptors, and as such are involved in a large array of developmental, homeostatic and pathological processes. They also interact with heparan sulfate (HS), the functional consequences of which depend on the respectiv...

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Bibliographic Details
Main Authors: Yoan R. Monneau, Lingjie Luo, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Romain R. Vivès, Françoise Baleux, Umesh R. Desai, Fernando Arenzana-Seidedos, Hugues Lortat-Jacob
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
chemokine
glycosaminoglycan
cxcl13
heparan sulfate binding site
heparan sulfate sequence
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170133

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170133

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