Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Abstract Mutation-derived neoantigens represent an important class of tumour-specific, tumour rejection antigens, and are attractive targets for TCR gene therapy of cancer. The majority of such mutations are patient-specific and targeting these requires a fully personalized approach. However, some m...

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Bibliographic Details
Main Authors: Vanessa M. Tubb, Deborah S. Schrikkema, Nathan P. Croft, Anthony W. Purcell, Carsten Linnemann, Manon R. Freriks, Frederick Chen, Heather M. Long, Steven P. Lee, Gavin M. Bendle
Format: Article
Language:English
Published: BMJ Publishing Group 2018-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Neoantigens
TCR gene therapy
CALR
FBXW7
Immunotherapy
Online Access:http://link.springer.com/article/10.1186/s40425-018-0386-y

Internet

http://link.springer.com/article/10.1186/s40425-018-0386-y

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