Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex <i>In Vitro</i>

Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex <i>In Vitro</i>

The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) <i>in vitro</i> and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, <i>in vitro<...

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Bibliographic Details
Main Authors: Adele Boccuto, Filippo Dragoni, Francesca Picarazzi, Alessia Lai, Carla Della Ventura, Carla Veo, Federica Giammarino, Francesco Saladini, Gianguglielmo Zehender, Maurizio Zazzi, Mattia Mori, Ilaria Vicenti
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
sofosbuvir
Zika virus
genetic barrier
<i>in vitro</i> selection
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/22/5/2670

Internet

https://www.mdpi.com/1422-0067/22/5/2670

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