Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis

Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis

In normal conditions gut homeostasis is maintained by the suppressive activity of regulatory T cells (Tregs), characterized by the expression of the transcription factor FoxP3. In human inflammatory bowel disease, which is believed to be the consequence of the loss of tolerance toward antigens norma...

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Bibliographic Details
Main Authors: Martina Di Giovangiulio, Angelamaria Rizzo, Eleonora Franzè, Flavio Caprioli, Federica Facciotti, Sara Onali, Agnese Favale, Carmine Stolfi, Hans-Joerg Fehling, Giovanni Monteleone, Massimo C. Fantini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Treg cells
Tbet
Th1-like Tregs
inflammatory bowel disease
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02158/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02158/full

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