Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

Abstract Background KCNH family of potassium channels is responsible for diverse physiological functions ranging from the regulation of neuronal excitability and cardiac contraction to the regulation of cancer progression. KCNH channels contain a Per-Arn-Sim (PAS) domain in their N-terminal and cycl...

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Bibliographic Details
Main Authors: Ze-Jun Wang, Purushottam B. Tiwari, Aykut Üren, Tinatin I. Brelidze
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
PAS domain
CNBH domain
Drug screening
Online Access:http://link.springer.com/article/10.1186/s40360-019-0324-8

Internet

http://link.springer.com/article/10.1186/s40360-019-0324-8

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