Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.

Bibliographic Details
Main Authors:	Susanne Laukoter, Robert Beattie, Florian M. Pauler, Nicole Amberg, Keiichi I. Nakayama, Simon Hippenmeyer
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14077-2

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spelling	doaj-30a406ce09274ca2817830f81bfa62fe2021-05-11T08:13:37ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-14077-2Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex developmentSusanne Laukoter0Robert Beattie1Florian M. Pauler2Nicole Amberg3Keiichi I. Nakayama4Simon Hippenmeyer5Institute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaDepartment of Molecular and Cellular Biology, Kyushu UniversityInstitute of Science and Technology AustriaHow the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.https://doi.org/10.1038/s41467-019-14077-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer
spellingShingle	Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development Nature Communications
author_facet	Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer
author_sort	Susanne Laukoter
title	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_short	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_full	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_fullStr	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_full_unstemmed	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_sort	imprinted cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.
url	https://doi.org/10.1038/s41467-019-14077-2
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Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

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