Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.
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Nature Publishing Group
2020-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-14077-2 |
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doaj-30a406ce09274ca2817830f81bfa62fe2021-05-11T08:13:37ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-14077-2Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex developmentSusanne Laukoter0Robert Beattie1Florian M. Pauler2Nicole Amberg3Keiichi I. Nakayama4Simon Hippenmeyer5Institute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaDepartment of Molecular and Cellular Biology, Kyushu UniversityInstitute of Science and Technology AustriaHow the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.https://doi.org/10.1038/s41467-019-14077-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer |
spellingShingle |
Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development Nature Communications |
author_facet |
Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer |
author_sort |
Susanne Laukoter |
title |
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
title_short |
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
title_full |
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
title_fullStr |
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
title_full_unstemmed |
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
title_sort |
imprinted cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-01-01 |
description |
How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival. |
url |
https://doi.org/10.1038/s41467-019-14077-2 |
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