A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs.

A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs.

Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8. The region contains LHX3, which codes for a transcription factor ess...

Full description

Bibliographic Details
Main Authors: Annemarie M W Y Voorbij, Frank G van Steenbeek, Manon Vos-Loohuis, Ellen E C P Martens, Jeanette M Hanson-Nilsson, Bernard A van Oost, Hans S Kooistra, Peter A Leegwater
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3223203?pdf=render

Internet

http://europepmc.org/articles/PMC3223203?pdf=render

Similar Items