In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection

In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection

In this study, we developed injectable intratympanic hyaluronic acid (HA) depots for the treatment of hearing loss. We prepared an injectable click-crosslinking formulation by modifying HA with tetrazine (HA-TET) and trans-cyclooctene (HA-TCO), which crosslinked to form an HA depot (Cx-HA). Preparat...

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Bibliographic Details
Main Authors: Hyeon Jin Ju, Mina Park, Ji Hoon Park, Gi Ru Shin, Hak Soo Choi, Myung-Whan Suh, Moon Suk Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Materials
Subjects:
intratympanic injection
hyaluronic acid
click-crosslinking
near-infrared fluorescence
depot
Online Access:https://www.mdpi.com/1996-1944/13/14/3070

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https://www.mdpi.com/1996-1944/13/14/3070

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