Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in de novo guanosine monophosphate (GMP) synthesis. In cultured cells, IMPDH polymerizes into micron-scale filamentous structures when GMP synthesis is inhibited by depleti...

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Bibliographic Details
Main Authors: S. John Calise, Georges Abboud, Hideko Kasahara, Laurence Morel, Edward K. L. Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
cell proliferation
cytoophidia
enzyme polymerization
IMPDH
lymphocytes
purine synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02789/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02789/full

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