Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke

Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke

Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not been fully investigated. Here, we examined the...

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Bibliographic Details
Main Authors: Yuhualei Pan, Dan Tian, Huan Wang, Yushang Zhao, Chengjie Zhang, Song Wang, Dan Xie, Dong Zhang, Yanbing Zhu, Yongbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microglia
perforin
immunity
ischemic stroke
cytotoxicity
neurogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.664312/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.664312/full

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