Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Toxoplasma gondii Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production

Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Toxoplasma gondii Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production

Heme oxygenase-1 (HO-1) enzyme exerts beneficial effects at the maternal-fetal interface, especially in trophoblasts, being involved in survival and maturation of these cell phenotypes. Trophoblast cells play essential roles throughout pregnancy, being the gateway for pathogens vertically transmitte...

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Bibliographic Details
Main Authors: Marcos Paulo Oliveira Almeida, Caroline Martins Mota, Tiago Wilson Patriarca Mineo, Eloisa Amália Vieira Ferro, Bellisa Freitas Barbosa, Neide Maria Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
BeWo villous trophoblast cells
HTR-8/SVneo extravillous trophoblast cells
heme oxygenase-1
interleukin-6
p38 MAPK
Toxoplasma gondii
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.659028/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.659028/full

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