IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

Abstract Background Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able to produce the IFN-λ4 protein. Patients with hepat...

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Bibliographic Details
Main Authors: Gabriela Samayoa-Reyes, Conner Jackson, Sidney Ogolla, Katherine Sabourin, Adeola Obajemu, Arlene E. Dent, Ludmilla Prokunina-Olsson, Rosemary Rochford
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Malaria
Innate Immunity
Type III Interferon
IFN-λ4
Online Access:https://doi.org/10.1186/s12936-021-03689-z

Internet

https://doi.org/10.1186/s12936-021-03689-z

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