IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children
Abstract Background Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able to produce the IFN-λ4 protein. Patients with hepat...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-04-01
|
Series: | Malaria Journal |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-021-03689-z |