H3 Relaxin Alleviates Migration, Apoptosis and Pyroptosis Through P2X7R-Mediated Nucleotide Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation in Retinopathy Induced by Hyperglycemia

H3 Relaxin Alleviates Migration, Apoptosis and Pyroptosis Through P2X7R-Mediated Nucleotide Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation in Retinopathy Induced by Hyperglycemia

Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with a structure similar to insulin, which has been reported to be effective in diabetic cardiomyopathy mod...

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Bibliographic Details
Main Authors: Kelaier Yang, Jiannan Liu, Xiaohui Zhang, Ziqi Ren, Lei Gao, Ying Wang, Wenjian Lin, Xuefei Ma, Ming Hao, Hongyu Kuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
relaxin
NLRP3 inflammasome
diabetic retinopathy
P2X7
diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.603689/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.603689/full

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