Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant

Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant

Summary: Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutan...

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Bibliographic Details
Main Authors: Marie Antoine, Kristin L. Patrick, Johann Soret, Pauline Duc, Florence Rage, Rebecca Cacciottolo, Kelly E. Nissen, Ruben J. Cauchi, Nevan J. Krogan, Christine Guthrie, Yannick Gachet, Rémy Bordonné
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219305553

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http://www.sciencedirect.com/science/article/pii/S2589004219305553

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