Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

Background: We evaluated the role of the aldosterone blocker spironolactone in attenuating long-term pressure overload-induced cardiac remodeling and heart failure (HF) in spontaneously hypertensive rats (SHR). Methods and Results: Thirteen month-old male SHR were assigned to control (SHR-C, n=20) o...

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Bibliographic Details
Main Authors: Marcelo D.M. Cezar, Ricardo L. Damatto, Luana U. Pagan, Aline R.R. Lima, Paula F. Martinez, Camila Bonomo, Camila M. Rosa, Dijon H.S. Campos, Antonio C. Cicogna, Mariana J. Gomes, Silvio A. Oliveira-Jr, Daniella A. Blotta, Marina P. Okoshi, Katashi Okoshi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Aldosterone antagonist
Cardiac remodeling
Collagen
Ventricular function
Papillary muscle
Spontaneously hypertensive rat
Online Access:http://www.karger.com/Article/FullText/430310

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http://www.karger.com/Article/FullText/430310

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