Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis

Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis

Mitochondrial metabolic dysfunction is often seen in cancers. This paper shows that the defect in a mitochondrial electron transport component, the cytochrome c oxidase (CcO), leads to increased glycolysis and carcinogenesis. Using whole genome microarray expression analysis we show that genetic sil...

Full description

Bibliographic Details
Main Authors: Dawei W. Dong, Satish Srinivasan, Manti Guha, Narayan G. Avadhani
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Genomics Data
Subjects:
Genome expression
Functional analysis
Tumor progression
Mitochondrial metabolic dysfunction
Cytochrome c oxidase defects
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596015001804

Internet

http://www.sciencedirect.com/science/article/pii/S2213596015001804

Similar Items