Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis
Mitochondrial metabolic dysfunction is often seen in cancers. This paper shows that the defect in a mitochondrial electron transport component, the cytochrome c oxidase (CcO), leads to increased glycolysis and carcinogenesis. Using whole genome microarray expression analysis we show that genetic sil...
Main Authors: | Dawei W. Dong, Satish Srinivasan, Manti Guha, Narayan G. Avadhani |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-12-01
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Series: | Genomics Data |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015001804 |
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