Metal chaperones prevent zinc-mediated cognitive decline

Metal chaperones prevent zinc-mediated cognitive decline

Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse. ZnT3 has been shown to decline with age and in Alzheimer's disease (AD) and is crucially involved in learning and memory....

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Bibliographic Details
Main Authors: Paul A. Adlard, Jacqui Parncutt, Varsha Lal, Simon James, Dominic Hare, Philip Doble, David I. Finkelstein, Ashley I. Bush
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Zinc
ZnT3
Clioquinol
Animal model
Cognition
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003830

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114003830

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