Mutant IDH1 Depletion Downregulates Integrins and Impairs Chondrosarcoma Growth

Mutant IDH1 Depletion Downregulates Integrins and Impairs Chondrosarcoma Growth

Chondrosarcomas are a heterogeneous group of malignant bone tumors that produce hyaline cartilaginous matrix. Mutations in isocitrate dehydrogenase enzymes (IDH1/2) were recently described in several cancers, including conventional and dedifferentiated chondrosarcomas. These mutations lead to the in...

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Bibliographic Details
Main Authors: Luyuan Li, Xiaoyu Hu, Josiane E. Eid, Andrew E. Rosenberg, Breelyn A. Wilky, Yuguang Ban, Xiaodian Sun, Karina Galoian, Joanna DeSalvo, Jinbo Yue, Xi Steven Chen, Marzenna Blonska, Jonathan C. Trent
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
chondrosarcoma
idh mutation
integrin
2-hydroxyglutarate
crispr/cas9
Online Access:https://www.mdpi.com/2072-6694/12/1/141

Internet

https://www.mdpi.com/2072-6694/12/1/141

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