Mutant IDH1 Depletion Downregulates Integrins and Impairs Chondrosarcoma Growth
Chondrosarcomas are a heterogeneous group of malignant bone tumors that produce hyaline cartilaginous matrix. Mutations in isocitrate dehydrogenase enzymes (IDH1/2) were recently described in several cancers, including conventional and dedifferentiated chondrosarcomas. These mutations lead to the in...
Main Authors: | Luyuan Li, Xiaoyu Hu, Josiane E. Eid, Andrew E. Rosenberg, Breelyn A. Wilky, Yuguang Ban, Xiaodian Sun, Karina Galoian, Joanna DeSalvo, Jinbo Yue, Xi Steven Chen, Marzenna Blonska, Jonathan C. Trent |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-01-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/12/1/141 |
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