Huntington's Disease and Striatal Signaling

Huntington's Disease and Striatal Signaling

Huntington’s Disease (HD) is the most frequent neurodegenerative disease caused by an expansion of polyglutamines (CAG). The main clinical manifestations of HD are chorea, cognitive impairment and psychiatric disorders. The transmission of HD is autosomal dominant with a complete penetrance. HD has...

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Bibliographic Details
Main Authors: Emmanuel eRoze, Emma eCahill, Elodie eMartin, Cecilia eBonnet, Peter eVanhoutte, Sandrine eBetuing, Jocelyne eCaboche
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Neuroanatomy
Subjects:
Axonal Transport
neurodegenerative disease
excitotoxicity
CAG repeat
energy deficits
transcriptional dysregulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00055/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00055/full

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