Pressure overload-induced mild cardiac hypertrophy reduces leftventricular transmural differences in mitochondrial respiratory chainactivity and increases oxidative stress

Pressure overload-induced mild cardiac hypertrophy reduces leftventricular transmural differences in mitochondrial respiratory chainactivity and increases oxidative stress

Objective: Increased mechanical stress and contractility characterizes normal left ventricular subendocardium (Endo) but whether Endo mitochondrial respiratory chain complex activities is reduced as compared to subepicardium (Epi) and whether pressure overload-induced left ventricular hypertrophy (L...

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Bibliographic Details
Main Authors: Michel eKINDO, Sebastien eGERELLI, Jamal eBOUITBIR, Anne-Laure eCHARLES, Joffrey eZOLL, Tam eHOANG MINH, Laurent eMONASSIER, Fabrice eFAVRET, Francois ePIQUARD, Bernard eGENY
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Physiology
Subjects:
Heart
Hypertrophy
Mitochondria
Aortic banding
Oxydative stress
Pressure overload
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00332/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00332/full

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