Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress

Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress

The brain endothelium is an integral element of the blood-brain barrier (BBB). Dysfunction of this formation due to increased generation of reactive oxygen species (ROS) progresses the establishment of neurological disorders including stroke and traumatic brain injury. Heat shock protein 90 inhibito...

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Bibliographic Details
Main Authors: Mohammad A. Uddin, Mohammad S. Akhter, Khadeja-Tul Kubra, Kathryn E. Whitaker, Summer L. Shipley, Landon M. Smith, Nektarios Barabutis
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Brain Disorders
Subjects:
Inflammation
Reactive oxygen species
Oxidative damage
P53
Heat shock protein 90 inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2666459320300019

Internet

http://www.sciencedirect.com/science/article/pii/S2666459320300019

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