The Interplay between Alpha-Synuclein Clearance and Spreading

Parkinson’s Disease (PD) is a complex neurodegenerative disorder classically characterized by movement impairment. Pathologically, the most striking features of PD are the loss of dopaminergic neurons and the presence of intraneuronal protein inclusions primarily composed of alpha-synuclein (α-syn)...

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Bibliographic Details
Main Authors: Tomás Lopes da Fonseca, Anna Villar-Piqué, Tiago Fleming Outeiro
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/5/2/435