Glycolysis Inhibition Alleviates Cardiac Fibrosis After Myocardial Infarction by Suppressing Cardiac Fibroblast Activation

Glycolysis Inhibition Alleviates Cardiac Fibrosis After Myocardial Infarction by Suppressing Cardiac Fibroblast Activation

Objective: To explore the role of glycolysis in cardiac fibroblast (CF) activation and cardiac fibrosis after myocardial infarction (MI).Method:In vivo: 2-Deoxy-D-glucose (2-DG), a glycolysis inhibitor, was injected into the abdominal cavity of the MI or sham mice every day. On the 28th day, cardiac...

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Bibliographic Details
Main Authors: Zhi-Teng Chen, Qing-Yuan Gao, Mao-Xiong Wu, Meng Wang, Run-Lu Sun, Yuan Jiang, Qi Guo, Da-Chuan Guo, Chi-Yu Liu, Si-Xu Chen, Xiao Liu, Jing-Feng Wang, Hai-Feng Zhang, Yang-Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart failure
myocardial infarction
glycolysis
fibroblast activation
cardiac fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.701745/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.701745/full

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