Effects of cyclic intermittent hypoxia on ET-1 responsiveness and endothelial dysfunction of pulmonary arteries in rats.

Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disorders and in some cases is complication of pulmonary hypertension. We simulated OSA by exposing rats to cyclic intermittent hypoxia (CIH) to investigate its effect on pulmonary vascular endothelial dysfunction. Sprague-Dawley Rat...

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Bibliographic Details
Main Authors: Zhuo Wang, Ai-Ying Li, Qiu-Hong Guo, Jian-Ping Zhang, Qi An, Ya-jing Guo, Li Chu, J Woodrow Weiss, En-Sheng Ji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589442?pdf=render