Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease.

Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease.

Emerging influenza viruses are a serious threat to human health because of their pandemic potential. A promising target for the development of novel anti-influenza therapeutics is the PA protein, whose endonuclease activity is essential for viral replication. Translation of viral mRNAs by the host r...

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Bibliographic Details
Main Authors: Rebecca M DuBois, P Jake Slavish, Brandi M Baughman, Mi-Kyung Yun, Ju Bao, Richard J Webby, Thomas R Webb, Stephen W White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3410894?pdf=render

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http://europepmc.org/articles/PMC3410894?pdf=render

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